Protein S Deficiency
There are three types of Hereditary Protein S Deficiency:
- Type I: decreased Protein S activity, low levels of free Protein S, normal levels of bound Protein S
- Type IIa - decreased Protein S activity, low levels of free Protein S, low levels of bound Protein S
- Type IIb - decreased Protein S activity, normal levels of free Protein S, normal levels of bound Protein S
It is also possible to have an acquired deficiency of Protein S, which is seen in some cases of DIC, DVT, PE, pregnancy and liver disease and during treatment with anticoagulants such as warfarin.
Protein S Deficiency occurs in about 1 in 20,000 people (1). Of those less than half develop thrombosis, usually between the ages of 20 and 30. Of all the inherited thrombophilic conditions, it remains the most difficult to diagnose (2).
Number of People in the UK with Protein S Deficiency:
- 1 in 20,000 of UK population (60m) -> 3000
Number of UK Cases of Protein S Deficiency With Thrombophilia:
- 3000 with PSD -> 2500 over 20 yrs old -> 40% affected -> 1000
Last updated: Sunday, 4th March 2012, © 2000-2013
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